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Properties and use of NDH (n-isobutyl-hexedrone)

johny / November 22, 2018
N-isobutyl-hexedrone is a new substitute for popular research chemical Hexen. At the moment, it is going through trial stages. The two synthetic compounds exhibit similar effects on human subjects, but the newly created compound requires extra caution and supervision.

Definition of the compound

Structurally, the substance belongs to the substituted cathinone group. It is derived from different precursors in lab environments only. Although cathinones are found in natural plant khat, substituted derivatives must be synthesized artificially. It is important to purchase any such research chemicals from trustworthy providers that guarantee compound purity. The structure of all chemicals belonging to the group includes a beta-keto group on their side chain of the molecule. A phenethylamine backbone is attached to the alpha carbon and has an alkyl group (its length varies) linked to it, and a ketone group is inside the beta carbon position. Other substitutions also exist. Aside from Hexen and NDH, the category of substituted cathinones includes dozens of compounds, such as Ethcathinone, Methcathinone, 3-MMC, and Benzedrone.

Medical use

At the moment, there are no formal studies describing the application of NDH in medical settings. Similarly, no research has been conducted with regard to Hexen. The prevailing hypothesis based on the structure suggests that the chemical functions as NDRI. This means it inhibits the reuptake of noradrenaline and dopamine into the synaptic cleft. NDRIs block certain transporter proteins. This boosts the amount of both active norepinephrine and dopamine neurotransmitters in the human brain. For example, an NDRI called Wellbutrin is widely used in depression treatment in the USA. It is thus possible to assume that NDH could have beneficial effects in the treatment of such patients, and some of the effects are similar to those of Synthetic Cannabinoids.

Effects observed at moderate doses

The chemical causes users to experience a surge of powerful physical and emotional sensations, in addition to beneficial cognitive changes. Here are a few of them:
  • boosted motivation;
  • better immersion in pursued activities;
  • improved analytical skills;
  • stimulation of ideation;
  • elevated music appreciation;
  • increased self-esteem;
  • pleasant tingling in the body;
  • enhanced sense of touch;
  • boosted stamina;
  • elevated concentration;
  • decreased appetite;
  • others.
Some of the possible adverse effects are:
  • xerostomia (dry mouth due to decreased flow of saliva);
  • elevated heartbeat;
  • profuse sweating;
  • increased blood pressure (due to vasoconstriction);
  • contamination;
  • erection issues;
  • teeth grinding (which is similar to MDMA).


Due to the lack of confirmed research findings, it is vital to avoid unsupervised consumption. Like with other synthetic substances like Benzodiazepines, excessive intake is potentially detrimental. Distribution While steroids and hormones could be produced naturally, NDH is made artificially. It is a recently introduced type of substituted cathinones, which appeared in the middle of 2000s. Such research chemicals may be purchased online in the form of powder, but they must never be self-administered.

Lab Research

Psychostimulants for lab research

As the name suggests, this group of research chemicals comprises compounds with the power to stimulate the human psyche. Such properties are exhibited by a substantial number of artificially made substances, such as synthetic cannabinoids. Since their emergence at the beginning of the 20th century, they have been introduced in therapeutic use in many countries as an effective prescription medicine for ADHD, obesity, and narcolepsy. These central nervous system stimulants modify the way it functions due to their psychoactive nature. Stimulants are opposite to depressants, which include such prescription medications as Benzodiazepines. The latter are also classified as sedative substances or ‘minor tranquilizers’. They slow down the processes in the human brain, while stimulants speed them up. The third type of substances with psychoactive properties is hallucinogens.


The substances have been shown to cause arousal, heightened alertness, and better motor activity in research subjects. Patients often report euphoria and acute wakefulness, enhanced ideation and concentration, along with suppressed appetite and boosted self-esteem. Short term physical effects include the following:
  1. blood pressure, blood sugar, breathing and heart rate increase;
  2. breathing passages open up;
  3. blood flow decreases;
  4. others.
The effects are linked to the workings of neurotransmitters. Under the influence of stimulants, concentrations of dopamine and norepinephrine rise. This is achieved through boosted release (the way methamphetamine works) or hindered reuptake (the way methylphenidate works). Some stimulants alter the levels of serotonin in the human brain, and they are usually classified as entactogens (or empathogens).


Psychostimulant drugs are a type of research chemicals useful for lab studies. They cause human physical and mental functions to improve, albeit temporarily. Psychomotor activity, which may be illustrated by playing football or brushing one’s teeth, receives a powerful boost. Such effects may be observed over a different period, depending on the subject and the dosage. Psychostimulants can be created in lab environments using different precursors, and they may be purchased online for scientific purposes. Like steroids and hormones, they may also occur naturally. Probably, the most common stimulant of this kind is caffeine.


Such different substances as nicotine, Ecstasy, methamphetamine, cocaine, and methylphenidate are all examples of stimulating compounds, and they fall into either of the following classes:
  1. sympathomimetics (both direct and indirect);
  2. non-sympathomimetics.
Direct sympathomimetics activate adrenoceptors in the subject’s sympathetic nervous system in a direct way. They also stimulate α, β, and D-receptors in different bodily tissues, such as eyes, hearts, and vascular smooth muscle. On the other hand, indirect agonists, such as cocaine and amphetamine, enhance the activity of endogenous catecholamines.

Medical application

In medical treatment and research, psychostimulant chemicals are often used against attention deficit and narcolepsy (random periods of deep sleep). Amphetamines help patients with narcolepsy, weight and attention issues. Cocaine is an effective anesthetic in cases of blood vessel constriction (vasoconstriction) and mucous membrane anesthesia. However, it is important to consider the high abuse potential of any stimulant compounds. Consequences of overdose may range from moderately unpleasant to lethal.