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Properties and use of NDH (n-isobutyl-hexedrone)

johny / November 22, 2018
N-isobutyl-hexedrone is a new substitute for popular research chemical Hexen. At the moment, it is going through trial stages. The two synthetic compounds exhibit similar effects on human subjects, but the newly created compound requires extra caution and supervision.

Definition of the compound

Structurally, the substance belongs to the substituted cathinone group. It is derived from different precursors in lab environments only. Although cathinones are found in natural plant khat, substituted derivatives must be synthesized artificially. It is important to purchase any such research chemicals from trustworthy providers that guarantee compound purity. The structure of all chemicals belonging to the group includes a beta-keto group on their side chain of the molecule. A phenethylamine backbone is attached to the alpha carbon and has an alkyl group (its length varies) linked to it, and a ketone group is inside the beta carbon position. Other substitutions also exist. Aside from Hexen and NDH, the category of substituted cathinones includes dozens of compounds, such as Ethcathinone, Methcathinone, 3-MMC, and Benzedrone.

Medical use

At the moment, there are no formal studies describing the application of NDH in medical settings. Similarly, no research has been conducted with regard to Hexen. The prevailing hypothesis based on the structure suggests that the chemical functions as NDRI. This means it inhibits the reuptake of noradrenaline and dopamine into the synaptic cleft. NDRIs block certain transporter proteins. This boosts the amount of both active norepinephrine and dopamine neurotransmitters in the human brain. For example, an NDRI called Wellbutrin is widely used in depression treatment in the USA. It is thus possible to assume that NDH could have beneficial effects in the treatment of such patients, and some of the effects are similar to those of Synthetic Cannabinoids.

Effects observed at moderate doses

The chemical causes users to experience a surge of powerful physical and emotional sensations, in addition to beneficial cognitive changes. Here are a few of them:
  • boosted motivation;
  • better immersion in pursued activities;
  • improved analytical skills;
  • stimulation of ideation;
  • elevated music appreciation;
  • increased self-esteem;
  • pleasant tingling in the body;
  • enhanced sense of touch;
  • boosted stamina;
  • elevated concentration;
  • decreased appetite;
  • others.
Some of the possible adverse effects are:
  • xerostomia (dry mouth due to decreased flow of saliva);
  • elevated heartbeat;
  • profuse sweating;
  • increased blood pressure (due to vasoconstriction);
  • contamination;
  • erection issues;
  • teeth grinding (which is similar to MDMA).


Due to the lack of confirmed research findings, it is vital to avoid unsupervised consumption. Like with other synthetic substances like Benzodiazepines, excessive intake is potentially detrimental. Distribution While steroids and hormones could be produced naturally, NDH is made artificially. It is a recently introduced type of substituted cathinones, which appeared in the middle of 2000s. Such research chemicals may be purchased online in the form of powder, but they must never be self-administered.